منابع مشابه
Stress Pathways and Heart Failure
UCSD—Salk Program in Molecular Medicine 1). Familial hypertrophic cardiomyopathy, which at first UCSD School of Medicine is not accompanied by chamber dilation, occurs due to La Jolla, California 92093 mutations affecting proteins in the sarcomere, which comprises the contractile machinery of heart muscle (Seidman and Seidman, 1999), while familial dilated car-The study of complex heart disease...
متن کاملOxidative stress and heart failure.
Oxidative stress, defined as an excess production of reactive oxygen species (ROS) relative to antioxidant defense, has been shown to play an important role in the pathophysiology of cardiac remodeling and heart failure (HF). It induces subtle changes in intracellular pathways, redox signaling, at lower levels, but causes cellular dysfunction and damage at higher levels. ROS are derived from se...
متن کاملStress echocardiography in heart failure
Echocardiography has the ability to noninvasively explore hemodynamic variables during pharmacologic or exercise stress test in patients with heart failure. In this review, we detail some important potential applications of stress echocardiography in patients with heart failure. In patients with coronary artery disease and chronic LV dysfunction, dobutamine stress echocardiography is able to di...
متن کاملOxygen, oxidative stress, hypoxia, and heart failure.
A constant supply of oxygen is indispensable for cardiac viability and function. However, the role of oxygen and oxygen-associated processes in the heart is complex, and they and can be either beneficial or contribute to cardiac dysfunction and death. As oxygen is a major determinant of cardiac gene expression, and a critical participant in the formation of ROS and numerous other cellular proce...
متن کاملHeart failure, oxidative stress and allopurinol.
Oxidative stress is one of the new and most intriguing pathogenetic hypotheses of heart failure; it involves various mechanisms such as endothelial dysfunction, mechano-energetic uncoupling and apoptosis. Xanthine oxidase, a key enzyme in purine catabolism, is overexpressed in patients with heart failure, and it is also an important source of oxidizing activity molecules (free radicals, superox...
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ژورنال
عنوان ژورنال: Biomed Data Journal
سال: 2015
ISSN: 2367-6477
DOI: 10.11610/bmdj.01300